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Alzheimer’s Disease

Pathology

  1. Amyloid-beta deposition in grey matter for Alzheimer’s disease. Accumulation of amyloid-beta then leads to oligomers which finally form plaques. It can alter intracellular Ca2+ levels. [LaFerla2008]
  2. Amyloid-beta can transmit between human [Jaunmuktane2015]
[LaFerla2008]Intracellular amyloid-β in Alzheimer’s disease (Figure 3 is a nice illustration of the process), Poster: Amyloid-β and tau in Alzheimer’s disease
[Jaunmuktane2015]Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy

Network Dysfunction

  1. Hypersynchrony and altered oscillatory rhythmic activity [Palop2016]
[Palop2016]Network abnormalities and interneuron dysfunction in Alzheimer disease

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