1. chronic pain, depression, sleep.
  2. Pain: “adapative” if it works to prevent futhure damage to tissue; “disruptive” if it goes beyond the biological functionalities.
  3. Disruptive pain or chronic pain usually cooccurs with depressive symptosm.

Quote from [Boakye2016]

Among people with a chronic pain diagnosis, sleep disturbance is a common clinical symptom, with 50% to 90% of people with pain reporting sleep disturbances of some description, with insomnia being the most common problem.

Fig.4 in [Boakye2016] privides good information about the intercorrelations between symptoms and physiological changes.

References and Notes

[Boakye2016](1, 2) Boakye, P. A., Olechowski, C., Rashiq, S., Verrier, M. J., Kerr, B., Witmans, M., … Dick, B. D. (2016). A critical review of neurobiological factors involved in the interactions between chronic pain, depression, and sleep disruption. Clinical Journal of Pain, 32(4), 327–336.

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